The mighty Medicine Faction has fallen to the evil hands of the Venom Clan. As they travel across the land, taking out each clan under the faction, Zhen Ziqiang becomes a test subject for the Elder of the Venom Clan. After being injected with various poisons, Ziqiang rises from the depths of hell as an Asura. Full of anger, he escapes and begins to plan his revenge as the sole survivor of his faction. Now, his goal is to destroy the entire Poison Faction and give them a taste of their own venom.