There are several medications you can try to help relieve the itching of eczema. Topical treatments including calamine lotion, which helps soothe the itching. Another topical option is an over-the-counter cream that contains one percent hydrocortisone. For severe itching, consider an oral over-the-counter antihistamine, such as Benadryl. Follow the instructions on the package, and remember that antihistamines may cause drowsiness.