According to the comments section, there are people who relate, but it's fine and GOOD that your friends' experiences differ. I'm glad.
Errr... about your referencing Game of Thrones fans?? Painting Artists? The people you're talking about are fans of a series or people who've developed a skill, not people with a certain physical feature. I THINK I understand what you're going for though, but the people taking offense (and why would they? Comparing Isaac to the mother of dragons is hilarious and actually a huge compliment!) would be taking offense to something about themselves that they chose to have, not something they were born with.
I understand it's a joke, and that FatZombie's joke actually has nothing to do with the person's appearance, but it wasn't clear to me right away which is why I explained my issue with it to him. And he cleared it up for me and even wrote a lovely little disclaimer to prevent others from getting confused <3
It's a shame that I've ruined your fun but I felt it was necessary to point out to him, and I did so as gently as I could. His response was gracious and we are on the same page now. You and I aren't seeing eye-to-eye but that's chill, we can agree to disagree. Feel free to go ahead and follow-up or further explain what you meant in your first comment, if you want.
Nah, you ain't ruining my fun, not so important in life for that to happen. But I'm just saying that is better if people chill out. FatZombie is an amazing artist and a kind hearted one. You're lucky to have someone to pat your head. Have fun!